| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I (A is single bond or 1-3C alkylene; B is NH or 1-2C alkylene; R<1> is alkyl, alkoxy, heterocyclyl, etc.; R<2> is phenyl, naphthyl, etc.; R<3> is alkyl, phenyl, etc.; R<4> is isopropyl, phenyl or cyclohexyl; R<5> and R<6> are H or alkyl or together represent cycloalkyl; R<7> is H or alkyl; R<8> is H or alkyl) and salt thereof. EXAMPLE:(2S,4S,5S)-5-{N-[N-Morpholinoacetyl-(1-naphthyl)-L-alanyl]-3-(4- thiazolyl)-L-alanyl}amino-6-cyclohexyl-4-hydroxy-2-(1-hydroxy-1-methyl ethyl)-N-[(2 S)-methylbutyl]hexanamide. USE:A renin inhibitor. PREPARATION:For example, a compound expressed by formula II is reacted with a compound expressed by formula III and the protecting groups, as necessary, are removed to afford the compound expressed by formula I.</p> |
