| 摘要 |
3,4,5-Trialkoxybenzaldehydes, notably 3,4,5-triamethoxybenzaldehyde, are prepared by hydrolyzing 5-bromo-4-hydroxy-3-methoxybenzaldehyde with an alkali metal hydroxide, in water and in the presence of a copper catalyst, and then directly sequentially (i.e., without separating any reaction intermediates) etherifying the 4,5-dihydroxy-3-methoxybenzaldehyde thus produced with a lower alkyl halide, in an aqueous medium and at a pH maintained at a value of from 6 to 12, optionally in the presence of a catalyst.
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