摘要 |
Benzimidazole-2-sulfonamide and imidazopyridine-2-sulfonamide derivatives corresponding to the general formula I: <IMAGE> I and their pharmaceutically acceptable salts, especially those of the formula in which: Z1 to Z4 represent a nitrogen atom or a substituted or unsubstituted carbon atom; R1 and R2 represent a hydrogen atom or an alkyl, alkylaryl, alkylcarbonylalkyl, alkylcarbonylaryl, alkylcarbonylheteroaryl, cycloalkyl, carboxyalkyl, acyl or nitro radical, or alternatively R1 and R2 can together form a linkage represented by a group X; R3 represents a hydrogen atom or an alkyl, aryl, heteroaryl, alkylaryl, hydroxyalkyl, alkylheteroaryl, mono-, bi- or tri-cycloalkyl, alkylamino, N-alkyl-alkylamino, alkylcarboxyalkyl, acyl, alkylthioalkyl, alkylsulfinylalkyl or alkylsulfonylalkyl, alkylthioaryl, alkylsulfinylaryl or alkylsulfonylaryl, alkylthioheteroaryl, alkylsulfinylheteroaryl or alkylsulfonylheteroaryl, alkylthioalkylaryl, alkylsulfinylalkylaryl or alkylsulfonylalkylaryl, alkylthioalkylheteroaryl, alkylsulfinylalkylheteroaryl or alkylsulfonylalkylheteroaryl, halogenoalkyl, cyanoalkyl, N-alkylaryl-alkylamino, N-alkyl-N-alkylaryl-alkylamino, N,N-dialkyl-alkylamino, alkylpiperazinyl, alkylpiperidinyl or alkylmorpholinyl radical; X represents -(CHR8)n-(CHR9)m- or -CR8=CR9-; R8 and R9 represent a hydrogen atom or a lower alkyl, aryl or heteroaryl radical; R10 represents a hydrogen atom, a radical -CH2OH, a radical -CH2Cl or a methylene radical (-CH2-); R1 can form a linkage with R10 in the case where R10 represents a methylene radical (-CH2-) and R1 itself represents a linkage; and R11 represents a hydrogen atom, an alkyl radical or a hydroxyalkyl radical.
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