| 摘要 |
DNA sequences encoding proteins processable by secretion leaders in recombinant hosts are described. The DNA sequences encode the NH2-terminal region of proteins that are cleaved from a secretion leader and may be secreted through the cell membrane and, if present, cell wall in some cases. Proteins encoded by the DNA sequence have an NH2-terminal amino acid sequence conforming to a consensus amino acid sequence that is processable by the particular secretion leader. DNA sequences encoding a consensus amino acid sequence processable by the diphterhia toxin secretion leader are disclosed. A novel Pseudomonas exotoxin and CSF-1 having NH2-terminal sequences conforming to a consensus sequence are exemplified.
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