Process for the synthesis of esters of dithiocarbamic acids by substitution of hydroxylated positions of mono- or polyhydroxylated molecules, products of this process and their uses.

摘要

Process for the specific synthesis of dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their applications. Process for preparing esters of dithiocarbamic acids having the formula (I), in which R1 and R2 are saturated or unsaturated alkyl radicals, substituted or not with carbon-containing groups or heteroatoms or else forming with the nitrogen atom a saturated or unsaturated cycle with or without heteroatoms from alcohols or polyols; said process is characterized in that at least one hydroxylated group of the mono- or polyhydroxylated molecule is transformed, at a preliminary stage, into a leaving group (Y) such as an iodide, tosylate, brosylate, triflate or imidazol sulphonate and in that the leaving group (Y) is displaced by the anion (II), R1 and R2 having the above-mentioned meaning, introduced in the form of salt, preferably lithium, in the appropriate medium. The newly-obtained derivates may be used as drugs, notably as immunomodulators.