| 摘要 |
Azacycloalkylalkanediphosphonic acids of formula <IMAGE> (I) wherein R is an azabicycloalkyl radical that is attached by way of the aza ring member and is composed of ring systems each containing from 3 up to and including 8 members, and alk is lower alkylene, and their salts, have regulatory properties with regard to the calcium metabolism and can be used as medicaments for the treatment of diseases that can be attributed to calcium metabolism disorders. They are prepared, for example, by: in a compound of formula <IMAGE> (II) wherein X1 is a functionally modified phosphono group and X2 is a free or functionally modified phosphono group, converting X1 and, where applicable, X2 into the free phosphono group(s).
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