| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as an intermediate for synthesizing a novel carcinostatic agent in high yield, by hydrolyzing a novel antibiotic BMG 162-aF2 with a dilute acid or a dilute alkali in a hydrous solution. CONSTITUTION:A novel antibiotic BMG 162-aF2 shown by the formulaIis hydrolyzed with an acid (e.g., formic acid, hydrochloric acid, etc.) or an alkali (e.g., sodium hydroxide, sodium carbonate, etc.) in a hydrous solution, to give N-[4-(3- aminopropyl)aminobutyl]-2,2-dihydroxyethaneamide shown by the formula II and (S)-7-guanidino-3-hydroxyheptaneamide shown by the formula III. The compound shown by the formula II has the following properties. Appearance: Hygroscopic paste or powder. Values of elemental analysis (as C9H21N3O3.2HCl): C 37.08, H 7.94, N 13.78, Cl 21.96, etc. by experimental value, etc. The compound shown by the formula III has the following properties. Appearance: Colorless crystalline powder. Melting point: 101-103 deg.C. Specific rotatory powder:[alpha]D<24>- 1 deg.(C1, water), etc.</p> |
