发明名称 |
PIPECOLIC ACID-CONTAINING PEPTRIDS, THEIR MANUFACTURE AND MEDICINE COMPOSITION |
摘要 |
Pipecolic acid-containing peptolides wherein the peptidic backbone is of at least 9 alpha -amino acid residues joined together by peptide bonds, particularly the compounds of formula I <CHEM> wherein the substituents have various significances, are disclosed. They can be prepared by isolation or derivation from an appropriate microorganism strain such as S 42508/F (NRRL 15761). They have interesting pharmacological, e.g. antifungal, chemotherapeutic drug resistance reversing and to some extent immunosuppressant and antiinflammatory properties. |
申请公布号 |
JPH02134399(A) |
申请公布日期 |
1990.05.23 |
申请号 |
JP19890247852 |
申请日期 |
1989.09.22 |
申请人 |
SANDOZ AG |
发明人 |
MIHAERU MORISU DOREIFUSU;GERUHARUTO ENMERU;MAKUSHIMIRIAN GURASUBERUGERU;KURAUSU RIYUUDEI;HANSU CHIERUTERU |
分类号 |
C12N1/14;A61K38/00;A61P31/00;A61P31/04;A61P35/00;C07K1/02;C07K1/113;C07K7/64;C07K11/02;C07K14/195;C07K14/41;C12P21/02;C12P21/04;C12R1/645 |
主分类号 |
C12N1/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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