发明名称 |
DERIVATIVES OF ALPHA-HANP AND THEIR PRODUCTION |
摘要 |
A peptide derivative of the formula <CHEM> wherein A is hydrogen or a hydrocarbon acyl having 2 to 18 carbon atoms which is substituted by an amino group at the alpha -position; B is F-Gly wherein F is a neutral alpha -amino acid residue, or NH-(CH2)nCO wherein n is an integer of 1 to 4; C is a neutral alpha -amino acid residue; and E is L-Arg or D-Arg; when A, B and C are hydrogen, Gly-Gly, and Met or Ile, respectively, E is D-Arg, or its pharmacologically acceptable salt has strong hypotensive and natriuretic activity; therefore it is useful as a therapeutic drug for hypertension, a diuretic, and a therapeutic drug for cardiac and cerebral circulatory diseases. |
申请公布号 |
EP0269220(A3) |
申请公布日期 |
1990.05.23 |
申请号 |
EP19870308586 |
申请日期 |
1987.09.29 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
FUJINO, MASAHIKO;WAKIMASU, MITSUHIRO;NISHIKAWA, KOHEI |
分类号 |
C07K7/08;A61K38/00;A61P7/10;A61P9/00;A61P9/12;A61P21/02;C07K1/00;C07K1/02;C07K1/113;C07K14/00;C07K14/575;C07K14/58;C07K14/60;D02G3/02;D02G3/06;D02G3/44;(IPC1-7):C07K7/10 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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