发明名称 |
DIAZEPINONES |
摘要 |
<p>Diazepinones Compounds of formula I are described, (I) wherein X represents the group -?HR, -?R or an oxygen atom and A represents the groups -NR1R2, wherein R1 and R2 represent hydrogen atoms or alkyl, cycloalkyl or phenylalkyl groups, n represents the number 0, 1 or 2, R3 represents a hydrogen atom, a hydroxy or alkyl group or a group -(CH2)n-N-R5R6 (R5 and R6 being lower alkyl groups) and R4 is an alkyl or phenylalkyl group. The compounds and their salts have favorable effects on heart rate and can be used as vagal pacemakers for treating bradycardia and bradyarrhythmia in human and veterinary medicine. Some of these compounds also have very good antithrombotic effects.</p> |
申请公布号 |
CA1269374(A) |
申请公布日期 |
1990.05.22 |
申请号 |
CA19860512576 |
申请日期 |
1986.06.26 |
申请人 |
THOMAE (DR. KARL) GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
EBERLEIN, WOLFGANG;TRUMMLITZ, GUENTER;ENGEL, WOLFHARD;MIHM, GERHARD;HAMMER, RUDOLF;MAYER, NORBERT;GIACHETTI, ANTONIO;DE JONGE, ADRIAAN |
分类号 |
A61K31/55;C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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