NEW SPERGUALIN RELATED COMPOUND, PRODUCTION AND USE THEREOF

摘要

NEW MATERIAL:A compound shown by formula I [X is-(CH2)1-5 or group shown by formula II; Y is H or residue after removal of OH from carboxy of amino acid or peptide; m is 0, 1 or 2; n is 1 or 2; with the proviso that Y is group except H when n=2 and m=0)] and a salt thereof. EXAMPLE:10-{N-(7-Guanidinoheptanoyl)-gamma-amino-beta(S)-hydroxybytano yl}-1,5,10- triazadecane. trihhydrochloride. USE:An immunosuppressive agent having chemical stability, strong activity and weak toxicity. PREPARATION:A protecting group is removed from a compound shown by formula III (X is -(CH2)1-5 or group shown by formula IV; R1 is amino protecting group; R2 is residue after removal of OH from carboxyl of amino acid or peptide containing amino protecting group or protected amino group) by reduction, acidolysis or hydrolysis to give a compound shown by formula I.