发明名称 |
Serine analogs of BU-3608 antibiotics. |
摘要 |
<p>Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof (I). These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine. <CHEM> wherein the serine is D-serine; R<1> and R<2> are independently H or C1-6 alkyl; and R<3> is H or beta -D-xylosyl; or a pharmaceutically acceptable salt thereof.</p> |
申请公布号 |
EP0368349(A2) |
申请公布日期 |
1990.05.16 |
申请号 |
EP19890120904 |
申请日期 |
1989.11.10 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SAWADA, YOSUKE;KAKUSHIMA, MASATOSHI;NISHIO, MAKI;MIYAKI, TAKEO;OKI, TOSHIKAZU |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P31/04;A61P31/10;C07H15/24;C07H15/244;C12N1/20;C12P19/56;C12R1/03 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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