HYDROXY-1,2,3,4-TETRAHYDROAMINOACRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

摘要

There are disclosed compounds having the formula I (see Formula I) where n is 1 or 2; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro or trifluoromethyl; R is hydrogen, benzyl or alkanoyl of 2 - 12 carbons, with the proviso that the group -OR may not be on the 1- or when n is 2, the 4- positions of the three ring system; and R1 and R2 are each independently hydrogen, loweralkyl or arylloweralkyl, b ut both may not be arylloweralkyl simultaneously, or alternatively R1 and R2 taken together may constitute the group (see formula II) NR3R4 where R3 and R4 are each independently loweralkyl; and a process for their preparation. The compounds can be used for the treatment of various memory dysfunctions characterized by decreased cholinergic function, such as Alzheimer's disease.