CHEMICALLY MODIFIED ISLET-ACTIVATING PROTEIN

摘要

The chemically modified protein of the present invention which comprises an islet-activating protein produced by bacteria belonging to the genus Bordetella and a polyethylene glycol moiety of the formula -O @CH2CH2O @@R wherein R is a protective group for hydroxyl and l is an integer of about 7 to 700, the polyethylene glycol moiety being bound to a primary amino group of the islet-activating protein, has a strong islet-activating activity and is lower in various side effects than non-modified IAP, so that it may be employed as a preventive and therapeutic drug for diabetes.