| 摘要 |
<p>Novel trisubstituted piperazine compounds of the formula (I): <CHEM> wherein A is an optionally substituted phenyl group, an optionally substituted condensed polycyclic hydrocarbon group, an optionally substituted hetero-cyclic group or a styryl group of the formula: Ar - CR<4> = CR<5> - wherein Ar is an optionally substituted phenyl group, and R<4> and R<5> are independently hydrogen or a lower alkyl group, X is methylene group, carbonyl group or thiocarbonyl group, G is a group of the formula: @CH2 @nZ-R<6> wherein n is an integer of 0 to 2, Z is a chemical bond, O, S, SO, SO2, CO, COO, CONR<7> or NR<7> (wherein R<7> is hydrogen, a lower alkyl group, a lower haloalkyl group, a lower alkenyl group or a lower alkoxycarbonyl group), and R<6> is hydrogen, a lower alkyl group, a lower haloalkyl group or a lower alkenyl group, provided that, when n is 0 and Z is chemical bond, R<6> is not hydrogen or a lower alkyl group, and R<1>, R<2> and R<3> are independently a lower alkyl group, and salts thereof, are useful as a platelet activating factor antagonist.</p> |
