摘要 |
<p>Polyether bis-phosphonic acid compounds are disclosed which have the formula (HO)2OP-R-(OR min )n-OR-PO(OH)2 where R is selected from the group consisting of methylene and ethylene, R min is selected from the group consisting of ethylene and ethylene substituted with one or more methyl groups, and n is an integer from 1 to 4, water soluble salts thereof, and esters thereof with alkyl groups having from 1 to 6 carbon atoms. Also disclosed is a novel preparation of certain of these compounds by reacting certain hydroxyalkylphosphonic acid dialkyl ester compounds with certain 2-benzyloxyalkyl organic sulfonates; reacting the intermediate formed therefrom with hydrogen or a hydrogen source; reacting the intermediate formed therefrom with a hydrogen ion acceptor and certain sulfonyl chlorides; and reacting the intermediate formed therefrom with certain hydroxyalkylphosphonic acid dialkyl ester compounds to form a polyether bis-phosphonic acid compound which may be hydrolyzed to form the polyether bis-phosphonic acid. Useful intermediates are disclosed which have the formulas <CHEM> HOR min -OR-PO(OR sec )2, HOR min -OR-PO(OH)2, and X-O2S-OR min -OR-PO(OR sec )2, wherein the above-indicated benzene rings of said formulas are optionally substituted with selected groups, wherein R and R min are as defined above, wherein R sec is an alkyl group having from 1 to 6 carbon atoms, and wherein X is selected from <CHEM> and alkyl groups having from about 1 to 6 carbon atoms.</p> |