| 发明名称 |
Purification, production and use of tumor necrosis factors. |
| 摘要 |
<p>A process for purifying mammalian TNF from a composition comprising the steps of (a) precipitating crude TNF from the composition; (b) fractionating TNF by anion exchange chromatography at a mild alkaline pH; (c) fractioning TNF by gel filtration; and (d) fractionating TNF by anion exchange chromatography at a slightly acidic pH.</p> |
| 申请公布号 |
EP0368367(A1) |
申请公布日期 |
1990.05.16 |
| 申请号 |
EP19890123527 |
申请日期 |
1985.12.19 |
| 申请人 |
BIOGEN, INC. |
发明人 |
FIERS,WALTER C.;FRANSEN,LUCIA M.;TAVERVIER,JAN HONORE LEO;MARMERNOUT,ANNE LOUISE MARIE |
| 分类号 |
G01N33/577;A61K;A61K38/00;A61K38/19;A61K38/21;A61K45/00;A61P33/02;A61P35/00;C07H;C07H21/00;C07H21/04;C07K;C07K1/18;C07K14/00;C07K14/52;C07K14/525;C07K14/555;C07K14/56;C07K14/565;C07K14/57;C12N;C12N15/00;C12N15/09;C12N15/28;C12N15/70;C12P;C12P21/00;C12P21/02;C12Q1/02;C12R1/19 |
主分类号 |
G01N33/577 |
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