2-(2-aminobenzyl or 2-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline derivatives

摘要

PCT No. PCT/FR87/00054 Sec. 371 Date Jan. 5, 1988 Sec. 102(e) Date Jan. 5, 1988 PCT Filed Mar. 4, 1987 PCT Pub. No. WO87/05295 PCT Pub. Date Sep. 11, 1987.Derivatives of 2-(2-aminobenzyl or 2-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline of the formula <IMAGE> in which each of substituents R1, R2, R3, R4, R5, R6, R7 or R8 may represent either a hydrogen atom, a straight or branched chain alkyl group, a straight or branched chain alkoxy group, a hydroxy group or corresponding esters, a phenoxy group, a benzyloxy group, a methylenedioxy bridge (-O-CH2-O-) when this substituent is connected with an adjacent carbon, a halogen, a nitro group, an amine function corresponding to primary or secondary or tertiary amine, or quarternary ammonium; each of substituents R9 or R10 may represent either a hydrogen atom, a straight or branched chain alkyl group, an arylalkyl group, an amine function corresponding to primary or secondary or tertiary amine or quarternary ammonium, or may each be oxygen atoms; each of substituents R11 or R12 may represent either a hydrogen atom, or a straight or branched chain alkyl group; R11 and R12 may also together form an oxygen atom; R13 may represent either a hydrogen atom, or a straight or branched chain alkyl group. These compounds have alpha -adrenergic activity, and more particularly either alpha 1 or alpha 2 adrenergic specificity.