发明名称 |
HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME |
摘要 |
Compounds selected from the group consisting of a compound of the formula <CHEM> and a compound of the formula <CHEM> wherein x is 1 or 2, Y is carbobenzoxy or benzoyl, and XR is <CHEM> have use as elastase enzyme inhibitors. Particularly potent are the L-proline diastereomers. Elastase Enzyme inhibitory compositions comprise a carrier and an elastase enzyme inhibiting amount of the compounds of the invention. A method of selectively inhibiting the enzyme elastase in an animal or a human in need of such treatment comprises administering to the animal or human an enzyme elastase inhibiting amount of one of the compounds of the invention or a composition thereof. A method of reducing corneal scarring or fibroblast proliferation comprises applying to an area of a subject's eye afflicted with the condition a corneal scar- fibroblast proliferation-reducing amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. A method of reducing neovascularization of corneal scar tissue comprises applying to an area of a subject's eye afflicted with the condition a neovascularization-inhibitory amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. |
申请公布号 |
AU4511089(A) |
申请公布日期 |
1990.05.14 |
申请号 |
AU19890045110 |
申请日期 |
1989.10.27 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
GEORGE A. DIGENIS;BUSHRA J. AGHA;CHARLES KHOURI |
分类号 |
C12N9/99;A61K38/00;A61K38/55;A61P27/02;A61P43/00;C07K5/06;C07K5/068;C07K5/083;C07K5/09;C07K5/10;C07K14/81 |
主分类号 |
C12N9/99 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|