| 摘要 |
NEW MATERIAL:A 2,3-diaminopropionic acid derivative expressed by formula I (R<1> is lower alkyl). EXAMPLE:Methyl (2S, 3S)-2-tritylamino-3-aminobutyrate. USE:A synthetic raw material for 3-amino-2-azetidinone derivatives expressed by formula II (R'' is H or organic residue) which is a synthetic intermediate for monobactam. PREPARATION:A compound expressed by formula III is reacted with hydrogen azide in the presence of triphenylphosphine and a dialkyl azodicarboxylate in an inert organic solvent, such as tetrahydrofuran, at -78 to +50 deg.C to form a novel azide compound expressed by formula IV, which is then reduced in the presence of 5% Pd/C, etc., in an inert organic solvent, such as ethyl acetate, at ambient temperature in H2 atmosphere to afford the compound expressed by formula I. |
