发明名称 |
Chelants possessing ortho ligating functionality and complexes thereof. |
摘要 |
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
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申请公布号 |
EP0367223(A2) |
申请公布日期 |
1990.05.09 |
申请号 |
EP19890120190 |
申请日期 |
1989.10.31 |
申请人 |
THE DOW CHEMICAL COMPANY |
发明人 |
WILSON, DAVID A.;GARLICH, JOSEPH R.;FRANK, RICHARD K.;MCMILLAN, KENNETH;SIMON, JAIME |
分类号 |
A61K31/135;A61K31/19;A61K31/195;A61K39/395;A61K51/00;A61K51/04;A61P35/00;A61P43/00;C07B59/00;C07C229/16;C07C229/42;C07C233/43;C07C233/54;C07C255/25;C07C255/30;C07C331/28;C07F5/00;G01N33/534 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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