发明名称 |
5-ALLYL-1,3-DIOXANE DERIVATIVES |
摘要 |
<p>The invention concerns novel 5-allyl-1,3-dioxane derivatives of the formula VII VII having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and optionally substituted aryl or arylalkyl, and benzene ring B is optionally substituted phenyl. The 5-allyl-1,3-dioxanes are useful intermediates in the preparation of 1,3-dioxan-5-ylalkenoic acid derivatives that antagonise one or more of the actions of thromboxane A2 (TXA2) and are of value in those disease conditions in which TXA2 is involved.</p> |
申请公布号 |
CA1268771(A) |
申请公布日期 |
1990.05.08 |
申请号 |
CA19890600591 |
申请日期 |
1989.05.24 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
BREWSTER, ANDREW G.;CAULKETT, PETER W.R. |
分类号 |
C07D319/06;A61K31/335;A61K31/35;A61K31/357;A61K31/36;A61P7/02;A61P9/08;A61P9/12;A61P11/08;A61P43/00;C07C;C07C59/48;C07C69/732;C07D309/06;C07D317/54;C07D319/04;C07D319/08;C07D325/00;C07D407/04;C07D407/10;C07D413/06;(IPC1-7):C07D319/04 |
主分类号 |
C07D319/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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