摘要 |
<p>The invention concerns a novel process for the manufacture of various aryloxyaliphatic aldehydes and related arylthio analogues, certain of which are novel, which are useful as chemical intermediates and which have been hitherto obtained by a process involving a low temperature reduction with an aluminium hydride reagent. The new process involves reacting a dihalogenohydroxyalkane of the formula: HO.C(R2)2.CHX2, wherein R2 is alkyl and X is chloro or bromo with a phenol or thiophenol in the presence of base and is applicable to large scale use.</p> |