发明名称 |
HUMAN LEUKOCYTE ELASTASE INHIBITORS AND METHODS OF PRODUCING AND USING SAME |
摘要 |
Compounds selected from the group consisting of a compound of formula (I), and a compound of formula (II), wherein x is 1 or 2, Y is carbobenzoxy or benzoyl, and XR is (III) have use as elastase enzyme inhibitors. Particularly potent are the L-proline diastereomers. Elastase enzyme inhibitory compositions comprise a carrier and an elastase enzyme inhibiting amount of the compounds of the invention. A method of selectively inhibiting the enzyme elastase in an animal or a human in need of such treatment comprises administering to the animal or human an enzyme elastase inhibiting amount of one of the compounds of the invention or a composition thereof. A method of reducing corneal scarring or fibroblast proliferation comprises applying to an area of a subject's eye afflicted with the condition a corneal scar- or fibroblast proliferation-reducing amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. A method of reducing neovascularization of corneal scar tissue comprises applying to an area of a subject's eye afflicted with the condition a neovascularization-inhibitory amount of a free or polymer-bound HLE inhibitory agent under conditions and for a period of time effective to attain the desired effect. |
申请公布号 |
WO9004409(A1) |
申请公布日期 |
1990.05.03 |
申请号 |
WO1989US04833 |
申请日期 |
1989.10.27 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
DIGENIS, GEORGE, A.;AGHA, BUSHRA, J.;KHOURI, CHARLES |
分类号 |
C12N9/99;A61K38/00;A61K38/55;A61P27/02;A61P43/00;C07K5/06;C07K5/068;C07K5/083;C07K5/09;C07K5/10;C07K14/81;(IPC1-7):A61K37/02;C07K7/06;C07K5/08 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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