发明名称 |
NOVEL DERMATAN SULFATE AND HEPARIN OLIGOSACCHARIDES HAVING ANTIATHEROSCLEROTIC ACTIVITY |
摘要 |
The invention comprises: mucopolysaccharides consisting of dermatan sulfate fragments in which the unsulfated uronic acid moieties have been opened, by oxidation of the C(2)-C(3) bonds with periodic acid, and the process for the preparation thereof; oligosaccharides obtained from heparin by a depolymerization process, which oligosaccharides have molecular weights ranging from 3.500-1.000 daltons; pharmaceutical compositions having antiatherosclerotic, arterial antithrombotic, anti-platelet aggregation activities, containing the above mentioned mucopolysaccharides and oligosaccharides. |
申请公布号 |
WO9004607(A2) |
申请公布日期 |
1990.05.03 |
申请号 |
WO1989EP01214 |
申请日期 |
1989.10.13 |
申请人 |
OPOCRIN S.P.A. LABORATORIO FARMACOBIOLOGICO |
发明人 |
MASCELLANI, GIUSEPPE;BIANCHINI, PIETRO |
分类号 |
C07H11/00;A61K31/00;A61K31/70;A61K31/715;A61P7/02;A61P9/00;A61P9/10;C08B37/00;C08B37/08;C08B37/10;(IPC1-7):C08B37/08;A61K31/725 |
主分类号 |
C07H11/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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