发明名称 |
Novel quinolyloxazole-2-ones useful as proteinkinase C inhibitors. |
摘要 |
<p>This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.</p> |
申请公布号 |
EP0365863(A2) |
申请公布日期 |
1990.05.02 |
申请号 |
EP19890118016 |
申请日期 |
1989.09.28 |
申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
JONES, WINTON DR.;CLAXTON, GEORGE P.;ROBINSON, PHILLIP J.;DAGE, RICHARD C.;CHENG, HSIEN C. |
分类号 |
A61P43/00;A61K31/47;A61P9/08;A61P9/12;A61P11/08;C07D215/14;C07D413/04 |
主分类号 |
A61P43/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|