发明名称 |
Endothelin DNA and use thereof. |
摘要 |
<p>Disclosed are (1) a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3, (2) a precursor protein and a mature peptide of endothelin-2 or human endothelin-3, (3) a transformant carrying a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3 and (4) a method for preparing mature endothelin-2 or endothelin-3 which comprises culturing the transformant described in (3), producing and accumulating a protein in a culture medium, and collecting the same. Cells transfected or transformed with the DNA allow large amounts of endothelin-2 or endothelin-3 to be produced, which causes the advantageous production of endothelin-2 or endothelin-3. Endothelin-2 and endothelin-3 can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.</p> |
申请公布号 |
EP0366016(A2) |
申请公布日期 |
1990.05.02 |
申请号 |
EP19890119505 |
申请日期 |
1989.10.20 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
MASAKI, TOMOH;YANAGISAWA, MASASHI;INOUE, AKIHIRO |
分类号 |
A61K38/00;C07K14/575;C12N1/21;C12N15/12;C12N15/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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