| 摘要 |
<p>A ruthenium-phosphine complex is of formula [RUX l (L)m(R-BINAP)]Yn (I) wherein R-BINAP represents a tertiary phosphine represented by <IMAGE> wherein R represents a hydrogen atom or a methyl group; X represents a halogen atom; L represents substituted or unsubstituted benzene or acetonitrile; Y represents a halogen atom, ClO4, PF6, BPh4 (wherein Ph represents a phenyl group) or BF4; when L is substituted or unsubstituted benzene, l represents 1, m represents 1, and n represents 1; and when L is acetonitrile, when l is 1, then m represents 2, and n represents 1, and when l is 0, then m represents 4, and n represents 2. 27 specific complexes are shown. Synthesis is by (a) RuCl2(Ar) + BINAP in a solvent at 25 to 50 DEG C; (b) [RuCl2 (Ar)]2 + Br or I salt of Li, Na or K, in water or in a mixture of water and methylene chloride and in presence of a quaternary ammonium or phosphonium halide; (c) [RuCl(Ar) BINAP]Cl + a Na, K, Li, Mg or Ag salt (MY); of ClO4, PF6 BPh4 or BF 4 , in an organic solvent; or (d) [RuCl(Ar) BINAP]Cl in an organic solvent, optionally with MY is heated at 25 DEG C-50 DEG C for 10-24 hours. The complex is used as catalyst in asymmetric hydrogenation, e.g. of methyl acetoacetate, and exhibits excellent catalytic activity to provide a product of high optical purity.</p> |
