| 摘要 |
PURPOSE:To selectively hydroformylate only vinyl group by reacting 1- vinyl-4-(2,2-dimethylethenyl)benzene with carbon monoxide and hydrogen in the presence of a transition metal complex carbonylation catalyst under specific conditions. CONSTITUTION:1-Vinyl-4-(2,2-dimethylethynyl)benzene is reacted with CO and H2 in the presence of a transition metal complex carbonylation catalyst under conditions of 40-150 deg.C, preferably 55-110 deg.C reaction temperature and 10-600kg/cm<2>, preferably 50-300kg/cm<2> total pressure of the CO and H2 to selectively hydroformylate only one (vinyl group) of unsaturated groups in the above- mentioned raw material. Thereby, alpha-[4-(2,2-dimithylethenyl) phenyl]propionaldehyde useful as an intermediate for alpha-(4-isobutylphenyl) propionic acid (trade name; Ibuprofen) excellent in anti-inflammatory effects is selectively obtained. |
