发明名称 |
Novel antimicrobial fluoroquinolonyl cephems. |
摘要 |
<p>Antimicrobial fluoroquinolonyl cephems of the formula: <CHEM> wherein (1) R<1> and R<2> are groups among those known in the art for substitution at the 7-position of an antimicrobially-active cephem; (2) R<3> is a substituted or unsubstituted, nitrogen-containing, heterocyclic moiety; and (3) R<4> is hydrogen, halogen, lower alkoxy or cyclic alkoxy, amino, nitro or cyano. Preferably, R<3> is substituted or unsubstituted piperazine, 3-aminopyrrolidine, or 3-aminomethylpyrrolidine. R<4> is preferably hydrogen or halogen.</p> |
申请公布号 |
EP0366640(A2) |
申请公布日期 |
1990.05.02 |
申请号 |
EP19890870151 |
申请日期 |
1989.10.20 |
申请人 |
NORWICH-EATON PHARMACEUTICALS, INC. |
发明人 |
DEMUTH, THOMAS PROSSER, JR.;WHITE, RONALD EUGENE |
分类号 |
A61K31/545;A61K31/546;A61P31/04;C07D501/00;C07D501/18;C07D501/26;C07D501/28;C07D501/32;C07D501/34;C07D501/48;C07D501/57 |
主分类号 |
A61K31/545 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|