| 摘要 |
Steroids with a 17-spiro substituent of 3,4 or 6 ring members of the formula <IMAGE> I wherein R1 is selected from the group consisting of carbocyclic aryl, heterocyclic aryl and aralkyl, R2 is a hydrocarbon of 1 to 18 carbon atoms in the alpha -or beta -position, the wavy line of the spiro ether indicates the oxygen is alpha -or beta -, X is selected from the group consisting of -CH=CH-CH2-CH2- and -(CH2)n-, n is 1, 2 or 4, the A and B rings have a structure selected from the group consisting of <IMAGE> (a) <IMAGE> (b) <IMAGE> (c) <IMAGE> and <IMAGE> R' and R'' are individually hydrogen or alkyl of 1 to 4 carbon atoms, Re is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, substituted alkyl of 1 to 6 carbon atoms and acyl and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable antiprogestomimetic activity.
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