发明名称 PROCESS FOR PREPARING STABLE INJECTABLE ANTIEMETIC COMPOSITION
摘要 4-Amino-5-chloro-N-(2-diethylamino)ethyl-2-(substd. alkoxy)benzamide antiemetics of formula (I) and their acid addn. salts contain a water miscible hydroxylic organic solvent or a water soluble polyhydric alcohol of sugar, as a stabilizing agent, which decreases the dielectric constant of the soln. In (I), R1, R2 and R3 are each H or methyl; R4 is H, C1-4 alkyl or phenyl. The agent is ethanol, propylene glycol, glycerol or mannitol.
申请公布号 KR900002745(B1) 申请公布日期 1990.04.28
申请号 KR19870003262 申请日期 1987.04.06
申请人 BRISTOL-MYERS SQUIBB CO 发明人 NASSAR MUNIR N;AGHARKAR SHREERAM N;BOGAROUS JOSEPH B
分类号 A61K9/08;A61K9/00;A61K31/165;A61K47/00;A61K47/10;A61K47/26;A61K47/36;(IPC1-7):A61K31/165 主分类号 A61K9/08
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