NOVEL S-ADENOSYL METHIONINE DECARBOXYLASE INHIBITORS

摘要

This invention relates to novel chemical compounds useful as S-adenosylmethionine decarboxylase inhibitors, of the formula H2N-Q- @-Al wherein Al represents 5'-deoxyadenosyl. represents adenosinyl, R represents H, methyl or ethyl and Q represents moieties of formulae Ia to If depicted as follows: wherein R1 is H or F, n is 1 or 2, V1 is H or CH3, V2 is H or COOH, and each of W, X, Y, and Z are H, F, Cl or Br. To the processes useful for their preperation and to their use in the treatment of a variety of condition and disease states associated with a rapid proliferation of cell growth.