摘要 |
A process for the asymmetric production of carboxylic acids or esters thereof is provided. The process comprises reacting a prochiral olefinic function and an alcoholic function or water with carbon monoxide, a single enantiomer of an optionally active compound, such as menthol, tartaric acid, tartaric acid esters, sugars, proteins and polypeptides, enzymes and chiral phosphines, and a catalyst. The catalyst comprises (a) a metal selected from palladium, rhodium ruthenium iridium and cobalt (preferably palladium) and copper. The reaction is optionally carried out in the presence of oxygen or air. The process is useful for making precursors for the pharmacologically important molecules ibuprofen and naproxen. |