NEW LONG-CHAIN GLYCOLIPID STRUCTURE

摘要

A substantially pure compound comprising an unbranched ceramide polysaccharide type 2 chain having the following structure: wherein Gal represents galactose, GlcNAc represents N-acetylglucoseamine, Fuc represents fucose and Cer represents ceramide. A substantially pure compound comprising an unbranched ceramide polysaccharide type 2 chain having the following structure: wherein Gal represents galactose, GlcNAc represents N-acetylglucoseamine, Fuc represents fucose, Cer represents ceramide and NeuAc represents sialic acid. Antibodies that are specific to portions of the above-described compounds, wherein the portions comprise the internal alpha 1->3 fucosyl residue and/or the terminal sialic acid residue. Immunogens for producing antibodies to the above-described compounds or portions thereof. A method of actively immunizing against tumors that express the above-described compounds.