THE RECEPTOR BINDING REGION OF EBVgp350

摘要

CR2 reactive polypeptides that correspond to amino acid residues in the amino terminal region of EBVgp350/220 and analogues thereof are described. Polypeptide sequences that correspond to at least 5 contiguous residues of the linear sequence of EBVgp350/220 and include at least one of residues 21-24 or 25-27 of the linear sequence bind to the CR2 receptor. Polypeptide aggregates comprising at least two CR2 reactive polypeptides find use as immunopotentiators, stimulating B cells. The aggregates also inhibit infection of B cells by EBV. Treatment methods and diagnostics are also described.