发明名称 |
PROCESS FOR THE PURIFICATION OF STREPTOKINASE |
摘要 |
B2619/Abs A process for the separation of streptokinase from contaminating proteins in a streptokinase-containing mixture, which comprises treating the mixture with a reducing agent to reduce disulphide bridges in the contaminating proteins to free thiol groups, contacting the mixture with a reagent R-X wherein R is a group capable of reacting with a free thiol group and X is a group R1 capable of reacting with a free thiol group or is a thiol-containing matrix, and thereafter separating the resulting chemically modified contaminating proteins from the mixture to provide streptokinase in a form substantially free of contaminating proteins.
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申请公布号 |
CA2000850(A1) |
申请公布日期 |
1990.04.19 |
申请号 |
CA19892000850 |
申请日期 |
1989.10.17 |
申请人 |
MANNIX, CHRISTOPHER J.;SMITH, RICHARD A. G.;LEWIS, CERI J. |
发明人 |
MANNIX, CHRISTOPHER J.;SMITH, RICHARD A. G.;LEWIS, CERI J. |
分类号 |
C07K14/315;C12N9/00;C12N9/70;C12R1/46;(IPC1-7):C12N9/70 |
主分类号 |
C07K14/315 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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