N-IMIDAZOLYL- AND N-IMIDAZOLYLMETHYL-DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS

摘要

The present invention relates to new N-imidazolyl and N-imidazolylmethyl derivatives of bicyclic compounds having general formula (I), wherein A is an alpha or beta group, in which R3 is hydrogen or C1-C6 alkyl, or a psi group, in which each of R4 and R5 independently is hydrogen or C1-C5 alkyl; Z is -CH2-, -O- or -S-; n is zero or 1; each of R and R1 is independently hydrogen or C1-C6 alkyl; R2 is -COCH2OH, -CH2OR', -COOR', -CONR'R'' or -CH=CH-COOR', in which each of R' and R'' independently is hydrogen or C1-C6 alkyl, and the pharmaceutically acceptable salts thereof; and wherein: a) when n is zero, then Z is -CH2- or -O-; whereas when n is one, then Z is -CH2-, -O- or -S-; b) when A is alpha or beta in which R3 is hydrogen, then n is one; and c) when, at the same time, A is beta in which R3 is hydrogen, Z is -CH2-, n is one and R2 is -COOR' wherein R' is as defined above, then at least one of R and R1 is other than hydrogen, which are useful in the treatment of diseases related to an enhancement of TxA2 synthesis.