| 发明名称 |
MODIFIED UROKINASE COMPOSITION |
| 摘要 |
<p>A novel urokinase of the formula: R-CO-NH urokinase wherein R is the residue of a water-soluble homo- or copolymer with a molecular weirht of 2,000 to 10,000, can be produced by reacting a carbonylimidazole derivative of the formula: <CHEM> with urokinase in a buffer solution at pH 6 to 11. The product is resistible to urokinase inhibitors, highly stable in blood and serves as a thrombolytic agent having durable effect.</p> |
| 申请公布号 |
EP0154432(B1) |
申请公布日期 |
1990.04.11 |
| 申请号 |
EP19850301032 |
申请日期 |
1985.02.15 |
| 申请人 |
NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA ALSO KNOWN AS JAPAN CHEMICAL RESEARCH CO., LTD;KABUSHIKI KAISHA SANWA KAGAKU KENKYUSHO ALSO KNOWN AS SANWA KAGAKU KENKYUSHO CO., LTD. |
发明人 |
SAWAI, KIICHI;KURONO, MASAYASU;AWAYA, JUICHI;IWATA, TADAHIKO |
| 分类号 |
A61K38/00;A61K47/48;C12N9/72;C12N11/08 |
主分类号 |
A61K38/00 |
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