Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides

摘要

The present invention relates to novel compounds of the general formula <IMAGE> (I) wherein R is hydrogen atom or a trifluoromethyl, carboxy, C2-5alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C1-4alkylsulfonyl group; R1 is hydrogen atom or a linear or branched chain C1-4alkyl, C1-4alkylthio, C1-4alkylsulfonyl, benzylthio, benzylsulfonyl, phenyl, hydroxy or mercapto group; and R2 is hydrogen or chlorine atom, as well as their pharmaceutically acceptable salts. The compounds according to the invention possess diuretic and saluretic activity with an advantageous Na/K ratio.