| 摘要 |
PCT No. PCT/SE87/00020 Sec. 371 Date Nov. 18, 1987 Sec. 102(e) Date Nov. 18, 1987 PCT Filed Jan. 19, 1987 PCT Pub. No. WO87/04437 PCT Pub. Date Jul. 30, 1987.Novel indoloquinoxalines having substituents in 6-position containing cyclic groups, of the general formula I <IMAGE> I wherein R1 represents hydrogen or one or several preferably 1 to 4, similar or different substituents in the positions 1-4 and/or 7-10, selected from halogen, lower alkyl-/alkoxy group having not more than 4 carbon atoms, trifluoromethyl group, trichloromethyl group; X is a group <IMAGE> wherein Y is CH2, NH, O or S and a is 2, 3 or 4 and wherein also the bond -C=N- can be saturated; Z is alkyl having 1-6 carbon atoms, Cl, Br or CF3 and R3 represents hydrogen, lower alkyl-/cycloalkyl group having not more than 4 carbon atoms, and the physiologically acceptable addition products of the compounds with acids and halogen adducts are described. Also methods for preparing said compounds by reaction of a compound of the formula II <IMAGE> II with a reactive compound containing the residue -CHR3X or by rearranging a compound of the formula III <IMAGE> III by heating, are described. The novel indoloquinoxalines have antiviral effect and have effect against cancer.
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