发明名称 Aromatic derivatives, their preparation and their use as antimicrobial agents
摘要 The present invention relates to aromatic derivatives of the formula: <IMAGE> (I) in which: n represents an integer between 2 and 10; R1 and R2 are identical or different and represent a cycloalkyl containing 3 to 6 carbon atoms or an alkyl containing from 1 to 6 carbon atoms which is unsubstituted or substituted by a phenyl or benzyl group; or R1 and R2, together with the nitrogen atom to which they are bonded, form a heterocycle selected from pyrrolidin-1-yl, piperidino, azepin-1-yl, hexamethyleneimino, 4-methylpiperidino, 4-benzylpiperidino, 4-phenylpiperidino, 1,2,3,4-tetrahydroisoquinol-2-yl, morpholino and imidazol-1-yl groups; R3 represents a hydrogen, a halogen, a methyl or a phenyl; R4 represents a hydrogen, a halogen or a methyl; or R3 and R4, taken together with the benzene ring to which they are bonded, form a naphth-1-yl or naphth-2-yl group; Y represents a direct bond, a methyleneoxy group, a methylenethio group or a vinylene group; and R5 represents an alkyl containing from 5 to 18 carbon atoms, a cycloalkyl containing from 3 to 8 carbon atoms, an adamantyl, naphth-1-yl or naphth-2-yl group, an unsubstituted phenyl group or a phenyl group substituted by one or 2 substituents selected from halogen atoms, the trifluoromethyl group, the nitro group and the phenyl group; and to their salts with mineral or organic acids.
申请公布号 US4916156(A) 申请公布日期 1990.04.10
申请号 US19880178327 申请日期 1988.04.06
申请人 SANOFI 发明人 MOSSE, MADELEINE;PROIETTO, VINCENZO
分类号 A01N37/12;A01N37/36;A01N37/48;A01N39/00;A01N43/40;A01N43/42;A01N43/50;A23L3/34;A23L3/3526;A61K8/00;A61K8/30;A61K8/40;A61K8/41;A61K8/46;A61K8/49;A61K31/215;A61K31/415;A61K31/445;A61K31/47;A61K31/472;A61K31/535;A61K31/5375;A61K31/55;A61P31/04;A61Q5/02;A61Q11/00;C07C67/00;C07C213/00;C07C219/22;C07D211/14;C07D217/04;C07D233/54;C07D233/60;C07D295/08;C07D295/084 主分类号 A01N37/12
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