| 摘要 |
PURPOSE: To provide a chemotherapy product exhibiting a strong activity after oral administration and useful for curing of cancer by containing a platinum coordination compound and loperamide. CONSTITUTION: This platinum chemotherapy product is obtained by containing a platinum coordination compound of the formula R is H, methyl, ethyl or a 3-9C alkyl; A is Cl or hydroxyl only existing when the platinum is a state of Pt (IV); B is Cl or malonate; when R is H, B is not Cl} and loperamide. The product is compounded with a usual medicine carried or a diluent and formulated to a medicine for curing of cancer. The loperamide increases absorption of a platinum compound into systemic circulation after the oral administration and an antitumor activity is extremely enhanced. The platinum compound of the formula is carboplatin. |
