GRANULES HAVING CORE AND THEIR PRODUCTION

摘要

Granules having a core are produced by spraying core granules with a dispersion of a low substituted hydorxypropylcellulose (L-HPC), and, if necessary, simultaneously applying a dusting powder. The granules having a core thus obtained exhibit increased granule strength and improved disintegrating property as compared with those produced by known methods. An active ingredient such as a drug can be contained in the dispersion, dusting powder or core granules.