发明名称 |
PROCESS FOR PREPARING GRISEOLIC ACID DERIVATIVES |
摘要 |
<p>Griseolic acid and dihydrodesoxygriseolic acid derivatives having an alkyl or aralkyl group as a substituent on the amino group at the 6-position are prepared by reacting the unsubstituted compound with a compound R7-X (where R7 is alkyl or aralkyl and X is halogen or sulfonyloxy). The group first substitutes and quaternizes the 1-nitrogen atom. The compound is then subjected to an appropriate combination of temperature and pH to cause ring cleavage, rearrangement and ring closure involving the 6-amino group and this quaternized 1-nitrogen to give a 6-alkylamino or 6-aralkylamino derivative. The process enables the derivatives to be prepared in high yield by means of a simple process.</p> |
申请公布号 |
CA1267410(A) |
申请公布日期 |
1990.04.03 |
申请号 |
CA19860507750 |
申请日期 |
1986.04.28 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
KANEKO, MASAKATSU;KIMURA, MISAKO;MUROFUSHI, YOSHINOBU |
分类号 |
C07H19/16;C07H19/02;(IPC1-7):C07H19/16;C07H23/00 |
主分类号 |
C07H19/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|