PROCESS FOR PREPARING ALPHA-ARYL-4-SUBSTITUTED PIPERIDINE ALKANOL DERIVATIVES

摘要

An alpha-(p-ter-butyl phenyl)-4-(alpha-hydroxy-alpha-phenyl benzyl)- 1-piperidino butanol (I) having anti-histamine and antiallergy effect, is prepd. Thus 7g 4'-terbutyl-4-[4-(alphahydroxy-alpha- phenyl benzyl)piperidino -butyrophenon sodium salt in 150ml methanol is adjusted to weak alkaline by adding methanolic KOH and cooled. Then 0.8g hydrated sodium borate is added and stirred at 0-5≦̸C for 2 hr followed by condensing and recrystallizing to give 6.2g I (m.p. 145-146≦̸C) by the yield of 95%.