| 摘要 |
NEW MATERIAL:A compound of formula [X<1>-X<2> is CH2-O, CH2-CH2, etc.; GA and GB are alkyl, halogen or OR<1> (R<1> is H or alkyl); gA and gB are 0-3; one of RA and RB is H and the other is Y-COOR<1a> (Y is single bond, formula II, etc.; R<1a>-R<1c> are R<1>; m is 0-4); W<1> is S, O, N, CH, etc.; n is 0-4; W<2> is single bond, S, NR<1e> (R<1e> is R<1>); Z is formula III or IV (a is CH2, NH, O, S, etc.; b-d are CH or N; Q<1>-Q<3> are H, alkyl, benzyl, phenyl, NO2, etc.)], and a salt thereof. EXAMPLE:11-[(3-Pyridyl)methyl]amino-6,11-dihydrobenzo[b,e]oxcepin-2-ca rboxylic acid. USE:A TAX2-inhibiting agent. PREPARATION:For example, a compound of formula V (A<a> is OH, OR<4> or halogen; R<4> is alkyl; formula VI is formula VII) is reacted with a compound of formula VIII to give the corresponding compound of formula I.
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