| 摘要 |
PURPOSE:To provide a cerebral function improver and choline esterase inhibitor containing substituted amines including novel compounds and effective as a remedy for senile dementia and Alzheimers disease. CONSTITUTION:The objective agent contains, as an active component, a com pound of formula I[R<1> and R<2> are H, (substituted) hydrocarbon group or together with bonding N form a condensed heterocyclic group; R<3> is H, (substituted) hydrocarbon group or (substituted) acyl; R<4> is H or together with group R<3> forms group of formula II, formula III or (CH2)m+1 (m is 0-2); A is (CH2)l (l is 0-2) or CH=CH; X is one or more substituents; n is 4-7] or its salt {e.g., 2-[4-(N-benzyl-N-methyl)aminobutyl]-5-nitro-1H-isoindole-1,3-(2H)-dione hydrochlo ride}. The compound of formula I wherein R<1> is H or (OH-substituted) lower alkyl and R<2> is (substituted) alpha-aralkyl is novel. |
