| 摘要 |
The invention relates to tricyclic ketones of the general formula (I) <CHEM> wherein R represents a hydrogen atom or a C1-3alkyl group and physiologically acceptable salts and solvates thereof. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting. |
