PROTECTED BIOTIN DERIVATIVES

摘要

Processes for the preparation of biotinylated polynucleotides and analogues thereof and protected intermediate products for use in such processes are described and claimed. The processes may be conveniently used in the automated synthesis of biotinylated polynucleotide on a DNA synthesiser. The polynucleotides so prepared may be used as labelled probes e.g. as diagnostic tools for clinical and research uses.